The problem of mineral metabolism in chronic renal failure is becoming a public health problem in all countries of the world, which is associated with an increase in the overall survival of this category of patients. We have carried out a comprehensive study of mineral metabolism and some biomarkers of bone metabolism in the initial and terminal stages of chronic kidney disease. At the same time, we examined not only the baseline values, but also the indicators after the treatment. It was determined that after treatment some stabilization of the studied parameters is noted, however, in most cases of observations, they remain higher than in the control group. Based on the above literature review, our statistical data and their comparisons with the studies of other authors, we are more inclined to the concept of using a complex of biomarkers in the study of the state of mineral metabolism in patients with chronic kidney disease.