The problem of secondary osteoporosis in various diseases is becoming a public health problem in all countries of the world, which is associated with the high prevalence of this condition among patients, regardless of gender, with chronic renal failure, in women in the postmenopausal period, as well as among patients with pemphigus complicated by the development of glucocorticoid osteoporosis. In this regard, we conducted a systematic literature search and a study of patients with these diseases in order to identify potential secondary osteoporosis. Literature searches were conducted in PubMed and Google Scholar for the keywords mineral metabolism, secondary osteoporosis, and biochemical characteristics. Based on the analysis of the literature data and the results of our scientific work, it seems possible to conclude that the diseases during treatment in all cases are subject to cor-rection. The patterns of mineral metabolism disorders were revealed, which are characteristic simultaneously for all 3 studied pathologies (violation of calcium and phosphorus parameters).