The work is aimed at determining the content of triterpene saponins in plant raw materials Scutellaria galericulata L. and Scutellaria baicalensis Georgi depending on the age and morphological parts of the plant. Plants of the genus Lamiaceae (Scutellaria baicalensis Georgi and Scutellaria galericulata L.), which were cultivated and harvested in the form of aboveground and underground parts in the Astrakhan region, were chosen as the object of analysis. In the work, raw materials of one-year-old (2019), two-year-old (2020) and three-year-old plants (2021) were analyzed. The content (%) of triterpene saponins was determined by the spectrophotometric method in terms of ursolic acid according to the State Pharmacopoeia XIV. During the experiment, it was found that differences in the content in the aboveground and underground parts relative to plants of the first and second years of life were not observed, the most significant difference was determined for the third year of collection. Revealed the reliability of differences between the content of saponins in the aboveground and underground parts for each of the plants, which can be traced for three years. In addition, the aerial part is the richest in the accumulation of triterpene compounds. Significant differences in the content of triterpene compounds of Scutellaria baicalensis Georgi relative to Scutellaria galericulata L. were observed only in the third year of harvesting raw materials. The data obtained in the study characterize a promising opportunity for further study of plant raw materials Scutellaria baicalensis Georgi and Scutellaria galericulata L. as a promising source of biologically active substances, namely triterpene compounds.