The work is devoted to the method of obtaining isophorone in a microchannel. Numerical and experimental optimization of the process of obtaining isophorone in a microchannel has been carried out. Isophorone is an unsaturated cyclic ketone, widely used in industry as a solvent for nitrocellulose paints, as well as as an inter-mediate for the synthesis of other compounds. The synthesis was carried out in microchannels. Microchannels are channels with a diameter of less than 1 mm. Their main feature is the possibility of carrying out various types of reactions requiring high pressures and temperatures. Due to the small internal volume, all processes occurring in them are easily intensified, high accuracy and efficiency of the experiment can be achieved. Parameters such as reaction temperature and reagent consumption varied. A new approach to conducting the experiment was used, based on minimizing the control parameters used and combining them correctly. This approach requires high ac-curacy and reproducibility of the results, so the microchannels used in this work are the best choice for such tasks. A mathematical model of the reaction based on systems of equations of varying complexity has been developed. Three-dimensional and two-dimensional contour diagrams are constructed to visualize the mathematical model of the process. The best technological parameters of the process have been established.