English
Русский 86-94 p.
The result of human evolution and the development of industry was the emergence of global environmental problems on the planet. Pharmaceuticals is one of the rapidly developing industries and, as a result, a "major supplier of pollutants" to the environment. The search for methods to solve the problems of purification and inactivation of organic toxic pollutants is an important task of modern chemistry. The purpose of this study was to study the inactivation of drugs of the nitrofuran group by hydrogen peroxide in the presence of iron (II) ions.
The study of oxidative degradation of furacilin and furagin preparations by Fenton reagent was carried out. The effect of different concentrations of the oxidative system on the destruction of drugs was compared, optimal conditions for destructive processes were determined. The characteristics of the oxidative degradation of the two drugs are compared, the justification of the differences based on the chemical structure of the active substances is proposed.
The effectiveness of the Fenton system for the destruction of nitrofuran class drugs has been confirmed. Chemi-cal methods of destruction of organic pollutants are advanced and can be used for wastewater treatment of medical and pharmaceutical enterprises, as well as for local treatment facilities.
The study of oxidative degradation of furacilin and furagin preparations by Fenton reagent was carried out. The effect of different concentrations of the oxidative system on the destruction of drugs was compared, optimal conditions for destructive processes were determined. The characteristics of the oxidative degradation of the two drugs are compared, the justification of the differences based on the chemical structure of the active substances is proposed.
The effectiveness of the Fenton system for the destruction of nitrofuran class drugs has been confirmed. Chemi-cal methods of destruction of organic pollutants are advanced and can be used for wastewater treatment of medical and pharmaceutical enterprises, as well as for local treatment facilities.
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3. Barenbojm G.M., CHiganova M.A. Zagryaznenie vodnyh ob"ektov Podmoskov'ya lekarstvami, ih me-tabolitami i drugimi ksenobiotikami s farmakologicheskoj aktivnost'yu: problemy i puti ih resheniya. Vestnik RAEN. 2014. T. 14. № 2. S. 97 – 103.
4. Samojlenko N.N., Ermakovich I.A. Zagryaznenie municipal'nyh vod farmacevticheskimi preparatami i ih proizvodnymi. Vostochno-Evropejskij zhurnal peredovyh tekhnologij. 2013. T. 4. № 10 (64). S. 8 – 11.
5. Zhussupova G., Skvirskaya G., Reshetnikov V., Dragojevic-Simic V., Rancic N., Utepova D., Jakovljevic M. The evaluation of antibiotic consumption at the inpatient level in Kazakhstan from 2011 to 2018. Antibiotics. 2020. V. 9. I. 2. P. 57.
6. Stuart K.A., Welsh K., Walker M.C., Edrada-Ebel R. Metabolomic tools used in marine natural product drug discovery. Expert Opinion on Drug Discovery. 2020. V. 15. I. 4. P. 499 – 522.
7. Grekhneva E.V., Kudryavceva T.N., Klimova L.G., Efanov S.A. Patent na izobretenie 2734245 C1, 13.10.2020. Zayavka № 2020111852 ot 23.03.2020.
8. Liou M.J., Lu M.C., Chen J.N. Oxidation of explosives by Fenton and photo-Fenton processes. Water Re-search. 2003. V. 37. I. 3. P. 3172 – 3179.
9. Gutierrez-Mata A.G., Velazquez-Martínez S., Álvarez-Gallegos A., Hernández-Pérez J.A., Silva-Martínez S., Ahmadi M., Ghanbari F. Recent overview of solar photocatalysis and photo-Fenton processes for waster treatment. International Journal of Photoenergy. 2017. V. 2017. P. 8528063.
10. Lebedeva O.E., Solovyeva A.A., Ustinova M. N., Buchelnikov A. S. UV photolysis of several conventional pharmaceuticals: degradability and products. Himiya v interesah ustojchivogo razvitiya. 2021. T. 29. № 1. S. 52 – 60.
11. Zhelovickaya A.V., Dresvyannikov A.F., CHudakova O.G. Primenenie Perspektivnyh Okislitel'nyh Pro-cessov Dlya Ochistki Stochnyh Vod, Coderzhashchih Farmacevticheskie Preparaty (Obzor). Vestnik tekhnolog-icheskogo universiteta. 2015. T.18. №.20. S.73–79.
12. Ustinova M.N., Lebedeva O.E., Kurdupova V.I. Fotodestruktivnye prevrashcheniya benzojnoj kisloty i ee proizvodnyh. Izvestiya vuzov. Prikladnaya himiya i biotekhnologiya. 2017. T. 7. № 4. S. 16 – 23.
13. Nemchenko (Ustinova) M.N., Lebedeva O.E. Okislitel'naya destrukciya lekarstvennyh veshchestv. Voda: himiya i ekologiya. 2011. № 6. S. 30 – 34.
14. Ustinova M.N., Lebedeva O.E. Oxidative inactivation of drugs. Advances in Environmental Biology. 2014. V. 8. I.13. P. 31 – 33.